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In the U.S., most of the 27 million individuals taking antidepressant medications are women. In this review of 35 preclinical and 26 epidemiologic studies, investigators examined possible associations of antidepressant use with breast and ovarian cancers. The researchers also looked at the effect of industry sponsorship and performed a random-effects meta-analysis of the epidemiologic studies.
In the meta-analysis, a modest association was found between antidepressants and risk for breast or ovarian cancer (pooled odds ratio, 1.11); the effects seemed slightly stronger for selective serotonin reuptake inhibitors than for tricyclics. In the studies overall, 33% reported some association between antidepressants and cancer, and 67% reported eit…