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Divalproex sodium has been hypothesized to have neuroprotective properties and is often prescribed for neuropsychiatric disorders like epilepsy, bipolar disorder, and migraine, as well as off-label for behavioral problems. Preclinical studies have suggested that divalproex sodium may have neuroprotective effects. In this report, researchers focus on the medication's effect on brain volume and cognition in a subset of patients with mild-to-moderate Alzheimer disease (AD) enrolled in a 24-month, multicenter, placebo-controlled clinical study of divalproex for AD (JW Psychiatry Aug 29 2011). The study's findings were negative for prevention of agitation.
Eighty-nine participants had baseline and 12-month magnetic resonance imaging results of su…