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Targeting pathologic pathways in Alzheimer disease (AD) is crucial for developing preventive and curative strategies. To further this goal, researchers studied induced pluripotent stem cells (iPSCs) from six adults' fibroblasts. Donors were two people with familial AD and duplication of the amyloid precursor protein gene, two with sporadic AD, and two nondemented controls.
The iPSCs were processed into neurons. Compared with neurons from controls, those from both familial-AD participants and from one with sporadic AD had similar phenotypes. That is, secretion of amyloid-β (1–40) and active glycogen synthase kinase-3β (GSK-3β) and ratios of phosphorylated tau (p-tau) to total tau were all higher in these neurons than in control neurons. Both …