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Cannabis is known to impair motivation and cognition and to lower the threshold for psychotic symptoms, and endocannabinoid signaling has been implicated in etiological theories of schizophrenia (JW Psychiatry Jul 11 2011). Two research groups further explored these issues.
In Bossong and colleagues' crossover study, tetrahydrocannabinol (THC) or placebo was administered to 17 healthy subjects, who then took tests of working memory (short-term storage and manipulation of memory) and underwent functional magnetic resonance imaging (MRI). In subjects on placebo, increasingly complex memory tasks were associated with progressive linear increases in activity in brain regions that mediate working memory (e.g., left dorsolateral prefrontal cortex,…