In evidence-based medical practice, much depends on the evidence being solid.
We clinicians find out about new research findings through scientific journal articles, popular media, or sources such as Journal Watch. Recent reports raise some concerns about reporting in science — incomplete study information, fraud, and misrepresentation of results.
Incomplete Study Information
In making treatment decisions, we often depend upon systematic reviews (e.g., as published by the Cochrane Collaboration). The quality of these reviews depends on the availability of all relevant information. Earlier this year, authors1 engaged in updating a Cochrane review on an antiviral medication class argued that systematic reviews require the extensive unpublished clinical study reports that pharmaceutical manufacturers prepare for regulator…
Author
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)