A study in cognitively healthy, nondiabetic individuals with family histories of dementia
Diabetes and problems with elevated glucose appear to be risk factors for Alzheimer disease (AD) and cognitive dysfunction. These researchers examined whether higher fasting serum glucose levels affect the same brain regions associated with lower regional cerebral metabolic rates for glucose (rCMRgl) in AD.
The participants were 124 cognitively healthy individuals (mean age, 64) who did not have a diabetes history and who had a first-degree relative diagnosed with probable AD. Magnetic resonance imaging, positron emission tomography (PET), and cognitive tests were administered, with fasting serum glucose levels obtained during PET.
Higher fasting serum glucose levels were significantly associated with lower rCMRgl in several brain regions imp…
Reviewing Author
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)