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Cognitive remediation therapy (CRT) improves aspects of the core cognitive deficits in psychosis that are linked to dysfunction of prefrontal regions (JW Psychiatry Jan 14 2013). Investigators in Spain randomized 35 schizophrenia patients either to CRT (40 hourly sessions; 2 or 3 times weekly) directed at shifting cognitive sets and enhancing working memory and planning or to 40 hours of manual-based social skills training, which improves symptoms but not cognition. Patients and 15 healthy controls underwent neuropsychological testing, functional magnetic resonance imaging, and diffusion tensor imaging at baseline and after 4 months.
Only CRT improved executive function and verbal and nonverbal memory. After treatment, CRT patients exhibited…