NEPHROTIC SYNDROME FROM NSAIDS.

Kidney disease from nonsteroidal anti-inflammatory drugs (NSAIDs) is increasingly recognized. In adults, nephrotic syndrome from NSAIDs is well documented, but only three probable cases have been reported in children.

Robinson and associates report two additional children with nephrotic syndrome that was likely caused by NSAIDs. One, a 16-year-old girl, took multiple NSAIDs over a three- year period for musculoskeletal pains. Her renal biopsy was consistent with minimal-change disease. The second patient, a six-year-old boy, developed nephrotic syndrome four months after starting naproxen for arthritis. His biopsy showed interstitial nephritis. Known risk factors for NSAID- related nephrotic syndrome -- advanced age, diabetes mellitus, and a…