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Several drugs used to treat cardiovascular disease in diabetic patients can disturb glycemic control. Although some reports have linked angiotensin-converting-enzyme (ACE) inhibitors with hypoglycemia in diabetic patients, these drugs are not generally considered to be an important cause of hypoglycemia. This retrospective case-control study from the Netherlands examined this association. Using a hospital admissions database with information about drug prescriptions, researchers identified 94 diabetic patients who had hypoglycemia during a six-year period. They compared these cases with 654 randomly selected diabetic controls from the same cohort. Hypoglycemia was 2.5 times more frequent among insulin users than among users of oral antidiab…