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In any given year, approximately 5 percent of premenopausal women present to their physician with excessive menstrual bleeding. Typically, these women are treated with surgery or hormonal therapy, even though menorrhagia is not usually a hormonal problem. Since some data support the use of drugs that affect clotting, Irish investigators tested three such agents in 76 women with menstrual blood losses averaging over 150 ml.
The women were randomized to receive tranexamic acid (an antifibrinolytic), mefenamic acid (a prostaglandin synthetase inhibitor), or ethamsylate (a hemostatic agent) for the first five days of three consecutive periods; their blood loss was compared with that from three pretreatment control periods.
Ethamsylate did not red…