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Staphylococcus saprophyticus is a common cause of urinary tract infections (UTIs) in young women, but risk factors for this infection, other than sexual activity, and possibly season, are unclear. Researchers conducted a case-control study in a large HMO to evaluate use of spermicides in women with S. saprophyticus UTIs. Ninety-six sexually active young women with UTIs caused by S. saprophyticus and 629 women without UTIs were interviewed about their contraceptive practices.
In multivariate analysis, the odds ratio for UTI in women who used condoms coated with the spermicide nonoxynol 9 ranged from 6 to 10, depending on the frequency of intercourse. The OR was 3.7 for women with a history of UTI, and 2.5 for those with multiple sexual partne…