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Erectile dysfunction occurs in 35 percent to 75 percent of men with diabetes. This randomized, double-blind, placebo-controlled trial evaluated the effect of sildenafil (25 to 100 mg) in 268 diabetic men with at least 6 months of erectile dysfunction.
After 12 weeks of treatment, those assigned to sildenafil had improved sexual function over a wide range of self-reported measures, while there had been no change in most measures for the placebo group. Overall, 56 percent of the sildenafil group reported improved erections, compared with 10 percent of the placebo group. Adverse effects were significantly more common among those receiving sildenafil than those receiving placebo and included headache (11 percent vs. 2 percent) and dyspepsia (9 p…