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Caloric restriction has been shown to lengthen life in several different animals, including mammals. Scientists at the University of Wisconsin took advantage of a new technology -- silicone chips containing myriad nucleic acid sequences that represent genes -- to study the relation of biological age and caloric intake. They determined which genes were expressed (or not expressed) in the skeletal muscle of normal or calorie-restricted aging mice and in younger mice.
In the muscle of control aging mice, the expression of genes that are part of the stress response was markedly increased, whereas the expression of many genes involved in biosynthetic functions was markedly decreased. The researchers then examined aging mice of the same strain tha…