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Results from several studies show that diet and exercise can reduce the incidence of type 2 diabetes in certain populations. In this multicenter U.S. trial, 3234 adults at high risk for diabetes were randomized to 3 intervention groups: standard lifestyle recommendations plus metformin (850 mg twice daily); standard lifestyle recommendations plus placebo; or intensive lifestyle modification (goal, at least 7% weight reduction and 150 minutes of exercise weekly).
Enrollment criteria included body-mass index (BMI) of 24 or higher, fasting plasma glucose of 95 mg/dL to 125 mg/dL, and plasma glucose of 140 mg/dL to 199 mg/dL 2 hours after an oral glucose load. Mean baseline BMI was 34. During an average follow-up of 2.8 years, incidence of newly…