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Little is known about the natural history of uterine polyps and fibroids. In a prospective cohort study that involved 64 women older than 30, investigators attempted to estimate the incidence and regression rates of these common abnormalities. All women were asymptomatic initially, and 57 were premenopausal.
Sonography after saline instillation into the uterus (to visualize endometrial abnormalities) was performed twice (2.5 years apart; average age at second ultrasound, 44). Polyps regressed in 4 of 7 women who had polyps at the initial ultrasound. At the second ultrasound, 10 women had endometrial polyps (7 new and 3 persistent; 2.5-year cumulative incidence rate, 12%). Eleven women had 18 fibroids that were detected at initial ultrasound.…