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In many animal species, from worms to primates, caloric restriction slows aging and prolongs life (Journal Watch Sep 17 1999). But, does caloric restriction have the same effects in humans?
A team from the National Institute on Aging first confirmed that 3 biomarkers were associated with caloric restriction in rhesus monkeys: Mean body temperature and mean insulin level were lower and mean dehydroepiandrosterone sulfate (DHEA-S) level was higher in calorie-restricted monkeys than in controls. Then, the team evaluated data for more than 700 men who were followed for at least 25 years in the Baltimore Longitudinal Study of Aging. Cumulative survival was greater in men with lower body temperatures, lower insulin levels, or higher DHEA-S levels …