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For more than 50 years, clinicians have used endometrial biopsies from infertile women to diagnose luteal phase deficiency (LPD) and to guide treatment. Now results from an observational study that involved 130 healthy, regularly menstruating, fertile volunteers (age range, 18-35) suggest that this test is unwarranted.
The women underwent endometrial biopsy and measurement of serum estradiol and progesterone at randomly determined intervals (1 to 14 days) after the midcycle urinary luteinizing hormone surge. Three gynecologic pathologists independently evaluated each tissue specimen and dated the endometrial samples. None of the traditional dating criteria could reliably distinguish any specific fertile day or narrow interval of days within …