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Dental fluorosis, a common, primarily cosmetic, defect caused by excessive fluoride exposure during enamel formation, manifests as white spots, pits, or dark brown stains on tooth enamel. Factors other than fluoride have been implicated in fluorosis, and some research suggests that amoxicillin use during infancy is associated with fluorosis in primary teeth. To gather more information, researchers in Iowa analyzed data from 579 children (collected as part of a larger study). Children were examined for fluorosis in early-erupting permanent teeth (first molars and central incisors); parents completed questionnaires on amoxicillin use and other factors.
Amoxicillin use in infancy, particularly during the first 6 months of life, was significantl…