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Patients with unexplained laryngeal symptoms often receive proton-pump inhibitors (PPIs) for presumed laryngopharyngeal reflux (LPR). However, PPI therapy was ineffective in several small previously published randomized trials.
One new industry-supported randomized trial included 39 patients with at least 2 months of LPR symptoms (e.g., hoarseness, sore throat, throat clearing, voice loss), laryngoscopic findings thought to represent reflux, abnormal results on 24-hour esophageal pH monitoring, and no previous diagnosis of gastroesophageal reflux. Patients received pantoprazole (40 mg daily) or placebo. After 12 weeks, the proportions of patients with adequate symptom relief were similar in the two groups (40% vs. 42%). Laryngeal examination…