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No evidence of increased risk for breast cancer was found in the estrogen-only arm of the Women’s Health Initiative, yet some uncertainty remains because several retrospective studies had positive findings (Journal Watch Apr 25 2006). In this study, investigators examined national registry data from all 110,984 Finnish women older than 50 who used oral or transdermal estradiol, oral estriol, or vaginal estrogens for at least 6 months during 1994–2001. All had undergone hysterectomies, and none used progestogens.
In follow-up through 2002, 2171 cases of breast cancer were identified. Estradiol use, either orally or transdermally, for 5 years or more was associated with a 1.44-fold increased risk for breast cancer. The risk increased with dose…