Another Study of Early Goal-Directed Therapy for Severe Sepsis

With the intervention, the mortality rate dropped, although not significantly.

Early goal-directed therapy (EGDT) for sepsis and septic shock (i.e., a set of protocol-driven interventions to optimize hemodynamic measurements, delivered in the emergency department) was associated with reduced in-hospital mortality in a widely cited randomized trial from 2001 (31% for EGDT vs. 47% for standard care; Journal Watch Nov 16 2001). In a new before-and-after study, researchers in Charlotte, North Carolina, attempted to validate the previous findings.

Starting in late 2005, patients presenting to the emergency department with severe sepsis or septic shock were treated with EGDT, according to an algorithm that included monitoring of central venous pressure and central venous oxygen saturation and that mandated aggressive adminis…

Reviewing Author

Allan S. Brett, MD

Disclosures

Nothing to disclose

Allan S. Brett, MD

Disclosures

Nothing to disclose