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In the early years of the AIDS epidemic, pregnancy in HIV-infected women involved a host of social and biologic considerations, including the never-resolved question of whether pregnancy accelerated HIV disease progression. Now that combination antiretroviral therapy (ART) has changed the landscape of AIDS, Tennessee investigators have readdressed this question.
Of 759 women who received HIV care at a single Nashville clinic between 1997 and 2004, 139 had been pregnant at least once. Compared with the others, these women were younger, had higher median baseline CD4-cell counts, were more likely to receive combination ART, and, not surprisingly, had a substantially lower risk for progression to AIDS or death. In multivariate analysis controll…