Reproductive Problems in Fathers of Boys with Hypospadias

These fathers had lower sperm concentrations and counts and more urogenital disorders than controls.

Because some studies have suggested an association between paternal subfertility and hypospadias in male offspring, Dutch investigators conducted a case-control study of 64 fathers of boys with hypospadias and 349 partners of pregnant women recruited from the general population.

Fathers of boys with hypospadias had significantly lower sperm concentrations (54 million/mL vs. 81 million/mL) and total sperm counts (222 million/mL vs. 326 million/mL) than did controls. Moreover, 11 of the 64 case fathers had disorders of the urogenital system (hypospadias, cryptorchidism, and testicular cancer), whereas only 16 of the 349 presumably normal fertile men had one of these disorders. Among fathers of boys with hypospadias, 16% had received treatment …

Reviewing Author

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)