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Obese men without prostate cancer have lower prostate-specific antigen (PSA) concentrations than normal-weight men without prostate cancer, and obese men with prostate cancer have poorer outcomes than normal-weight men with prostate cancer. Investigators explored a possible connection between these two observations by studying PSA levels in 13,634 men (mean age, about 60) from three cancer cohorts; all had prostate cancer, diagnosed by needle biopsy prompted by elevated PSA level, and all had undergone radical prostatectomy.
Men were excluded if they received preoperative hormone therapy, radiation, or chemotherapy or if they had positive lymph nodes. Based on standard body-mass index and plasma volume calculations, 24% of the sample was obe…