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The progressive decline in testosterone levels as men age has led to suggestions that physical, functional, or cognitive benefits could accrue from testosterone supplementation later in life. In a double-blind Dutch study, 237 healthy men (mean age, 67) with low-normal circulating testosterone levels (mean baseline total testosterone level, 308 ng/dL) were randomly assigned to oral testosterone undecenoate (80 mg twice daily) or placebo for 6 months. More than 90% of participants used at least 80% of their assigned medication.
At 6 months, total, free, and bioavailable testosterone levels were actually slightly lower with the active preparation than with placebo; the investigators attribute this finding to measuring fasting (and not post-dos…