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Major injuries are a well-recognized risk factor for venous thrombosis; risk posed by minor injuries has not been fully studied. In a case-control study, researchers in the Netherlands enrolled more than 2400 consecutive patients with first venous thromboses and 3500 controls to assess risk for developing venous thrombosis after minor injury. Patients who were undergoing surgery, and those with malignancy, casts, or prolonged bed rest were excluded.
Nearly 290 adults with venous thromboses (11.7% of cases) and 4.4% of control subjects had experienced minor injuries (e.g., ankle sprain, knee sprain, “sural muscle rupture”) during the preceding 3 months; the odds ratio for developing venous thrombosis was 3.1 with a minor injury, and this risk…