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Thrombosis and inflammation are involved in the pathogenesis of acute cardiovascular events, but whether markers of these processes can predict short-term harm is unknown. Researchers studied the association between such markers and mortality in a prospective cohort of 377 patients with peripheral arterial disease. During 4 years of follow-up, 76 patients (20%) died; 31 died of cardiovascular disease.
Higher levels of d-dimer, C-reactive protein, and serum amyloid A were each associated significantly with higher all-cause mortality within 1 year, and from 1 to 2 years, but not 2 to 3 years after measurement, in survival analyses adjusted for age, sex, race, cardiovascular diseases, cancer, diabetes, smoking, and ankle-brachial index. A simil…