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In recent decades, consumption of sugar-sweetened soft drinks (which contain high-fructose corn syrup) has increased dramatically in the U.S., and, at the same time, the prevalence and incidence of gout also have increased. Since fructose consumption rapidly increases blood uric-acid levels, might fructose consumption contribute to risk for gout?
Investigators prospectively obtained dietary information from 46,393 male health professionals who did not have histories of gout. After 12 years of follow-up, 755 men had developed gout. In analyses adjusted for age, body-mass index, diuretic use, renal insufficiency, consumption of alcohol and meat, and other variables, consumption of one sugar-sweetened soft drink daily significantly increased ri…