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Cardiovascular disease is the leading cause of death among patients with chronic kidney disease (CKD). In the general population and in patients with established cardiovascular disease, statins lower risks for nonfatal cardiovascular events, cardiovascular deaths, and all-cause mortality. Do statins have similar benefits in patients with CKD?
An international team of investigators conducted a meta-analysis of 50 randomized trials in which any statin was compared with placebo, no treatment, or other statins; the trials involved more than 30,000 adults with CKD (defined as patients who had elevated serum creatinine levels or glomerular filtration rates, who were undergoing maintenance dialysis, or who had undergone kidney transplantation). Mos…