Steroid Therapy for Drug-Induced Acute Interstitial Nephritis

Chronic dialysis was required in 4 of 9 patients who did not receive steroids and in 2 of 52 steroid recipients — a significant difference.

Drugs are an important cause of acute interstitial nephritis (AIN). Although drug-induced AIN sometimes is treated with corticosteroids, no randomized trials have been conducted to evaluate this treatment. In this retrospective study, nephrologists in Spain assessed the effects of steroid therapy in 61 patients with biopsy-proven drug-induced AIN.

The most common offending agents were antibiotics (56%) and nonsteroidal anti-inflammatory drugs (37%); the presumed offending drug was stopped in all cases. Fifty-two patients received steroids, and 9 did not; no significant differences were noted between the groups in demographic characteristics, baseline serum creatinine levels, or highest serum creatinine level. Chronic dialysis was required in…

Reviewing Author

Allan S. Brett, MD

Disclosures

Nothing to disclose

Allan S. Brett, MD

Disclosures

Nothing to disclose