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Combination antiretroviral therapy (cART) has lowered morbidity and mortality from HIV infection dramatically in developed countries, but cART’s effect on life expectancy has not been described clearly on a population level.
Researchers combined data from 14 cohorts (involving 43,355 HIV-positive people) in Europe and North America who were antiretroviral-naive when they started cART after 1996. According to statistical techniques that estimate life expectancy from observed death rates, remaining life expectancy at age 20 increased from 36 years in 1996–1999 to 49 years in 2003–2005, and life expectancy at age 35 increased from 25 to 37 years during the same period. Mortality rates declined with later date of cART initiation and with longer …