Loading...
Transformation of adult cells into induced pluripotent stem (iPS) cells, first in mice (JW Jun 21 2007) and then in humans (JW Nov 29 2007), were landmark events: Suddenly, realizing the promise of human stem-cell therapy and avoiding the ethical concerns of harvesting stem cells from embryos became easier.
A multi-institutional team harvested skin fibroblasts from two sisters in their 80s who were suffering from a familial form of amyotrophic lateral sclerosis (ALS). The cells were transformed into iPS cells — with all the hallmarks and versatility of embryonic stem cells — and, then, with in vitro molecular signals, they were coaxed into becoming motor neurons and glial cells. In principle, the genetic defect in these cells could be correc…