Hyperinsulinism in Daughters of Mothers with Polycystic Ovary Syndrome

The authors suggest that hyperinsulinism may be the first and most common abnormality in the daughters of mothers with PCOS.

Hyperandrogenism and insulin resistance are two characteristics of polycystic ovary syndrome (PCOS), along with anovulation and polycystic ovaries. Although the genetic basis for the syndrome is complex, the disorder is known to cluster in families. In a case-control study exploring the ontogeny of this syndrome, 32 children born to women with PCOS were compared with 38 children of women without PCOS.

During a 2-hour glucose tolerance test, salivary insulin levels were significantly higher in late pubertal daughters (Tanner IV–V) of PCOS mothers than in controls. Interestingly, urinary luteinizing hormone levels were significantly lower in the PCOS daughters. Urinary testosterone levels were significantly elevated in midpubertal (Tanner II–I…

Reviewing Author

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Hyperinsulinism in Daughters of Mothers with Polycystic Ovary Syndrome

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Reviewing Author