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Observational studies suggest an association between use of acetaminophen and the development of asthma in children. Investigators assessed the relation between acetaminophen use during the first year of life or the 12 months before the study and development of wheeze, as recalled by parents or guardians, in 205,487 children aged 6 to 7 years in 31 countries.
In various analyses, controlling for numerous confounding variables and completeness of data, use of acetaminophen during the first year of life was significantly associated with wheeze compared with no use (odds ratio, 1.46 in the most complete analysis). Use in the previous 12 months showed a significant dose-response association with asthma symptoms (ORs ranged from 1.61 for use once…