Loading...
Most patients with type 2 diabetes mellitus eventually require insulin in addition to oral medications to achieve glycemic control. Insulin analogues with varying durations of action are available, but evidence that they are superior to older insulin preparations is sparse. In two studies, investigators addressed the use of insulin for type 2 diabetes.
In a randomized open-label Italian trial, 116 adults with type 2 diabetes that was uncontrolled (despite stable doses of metformin and sulfonylurea) added single bedtime doses of either insulin glargine (long-acting) or neutral protamine lispro (NPL; intermediate-acting; not available in the U.S.) to their regimens. Improvements in glycemic control were significant and similar in the two group…