HPV Testing Improves Yield of Cervical Cancer Screening

A meta-analysis of screening studies showed that HPV screening at 6-year intervals resulted in a very low number of high-grade lesions, especially in women older than 35.

Recognition that squamous cell carcinoma of the cervix is caused by human papillomavirus (HPV) and development of sensitive tests for the presence of HPV have resulted in many attempts to determine the most effective and cost-efficient algorithm for cervical cancer screening (JW Feb 27 2004).

To obtain additional information about the value of cytology and HPV testing for predicting high-grade cervical intraepithelial neoplasia or cancer (CIN3⁺), investigators obtained data from seven primary HPV screening studies that involved more than 24,000 women (>20,000 older than 35) in six European countries; each woman was screened at baseline and underwent at least one more test (colposcopy or repeat cytology or HPV testing) during follow-up (≤6 ye…

Reviewing Author

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

HPV Testing Improves Yield of Cervical Cancer Screening

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Reviewing Author