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Respiratory syncytial virus (RSV) is associated with hospitalization in children, but the total burden of disease among young children in the U.S. is poorly understood. The CDC conducted a prospective population-based surveillance study of children younger than 5 years with diagnoses of acute respiratory disease who were hospitalized or presented to emergency departments (EDs) or outpatient clinics in three U.S. cities during the RSV seasons between 2000 and 2004.
Nasal and throat swabs were obtained from 5067 children; 919 (18%) had confirmed RSV infection. Coinfecting viruses were identified in only 6% of samples. RSV was associated with 20% of hospitalizations, 18% of ED visits, and 15% of office visits for acute respiratory infections fr…