Is Prophylactic Bilateral Oophorectomy Associated with All-Cause Mortality?

Bilateral oophorectomy was associated with elevated hazard ratios for all-cause mortality, fatal plus nonfatal coronary heart disease, and stroke.

Bilateral oophorectomy often is performed at the time of hysterectomy for benign disease to prevent ovarian cancer. In a prospective, observational study, investigators assessed the long-term consequences of bilateral oophorectomy, which was performed in 56% of 29,000 women who underwent hysterectomy for benign disease.

During 24 years of follow-up and after adjustment for relevant risk factors, women who underwent bilateral oophorectomy had elevated risk for all-cause mortality (hazard ratio, 1.12), fatal plus nonfatal coronary heart disease (HR, 1.17), stroke (HR, 1.14), lung cancer (HR, 1.26) and all-cancer mortality (HR, 1.17). Bilateral oophorectomy was associated with lower risks for breast cancer (HR, 0.75), ovarian cancer (HR, 0.04),…

Reviewing Author

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Is Prophylactic Bilateral Oophorectomy Associated with All-Cause Mortality?

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Reviewing Author