Managing Skin and Soft-Tissue Infections in Children

Trimethoprim-sulfamethoxazole might not be effective as initial monotherapy for skin infections in children.

The emergence of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has complicated initial management of skin and soft-tissue infections in children. In a retrospective case-control study, investigators assessed the effectiveness of initial outpatient monotherapy with β-lactams, clindamycin, or trimethoprim-sulfamethoxazole (TMP-SMX) in 2096 children (age range, birth to 21 years) with nondrained noncultured skin infections at five pediatric centers in Philadelphia between 2004 and 2007. Use of clindamycin and TMP-SMX for initial treatment of skin infections in this population increased from 16% in 2004 to 62% in 2007. Cases were 104 children in whom treatment failed; controls were 480 children in whom treatment was s…

Reviewing Author

Howard Bauchner, MD

Disclosures

Grant / research supportHuman Resources and Services Administration; NIH; NIH-NHLBI; USDA; GlaxoSmithKline

Editorial boardsArchives of Disease in Childhood (Editor-in-Chief)

Howard Bauchner, MD

Disclosures

Grant / research supportHuman Resources and Services Administration; NIH; NIH-NHLBI; USDA; GlaxoSmithKline

Editorial boardsArchives of Disease in Childhood (Editor-in-Chief)

Managing Skin and Soft-Tissue Infections in Children

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Reviewing Author