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Osteoporotic Fractures in Men is a prospective study of healthy aging — with a focus on osteoporosis — in 6000 older U.S. men (age, ≥65). In a previous report from that study (JW Gen Med Apr 23 2009), one quarter of participants exhibited 25 hydroxyvitamin D [25(OH)D] levels lower than 20 ng/mL. Now, the researchers report on the relation between vitamin D levels and bone loss.
About 1300 participants underwent baseline measurement of serum 25(OH)D and bone-mineral density at the hip, followed by repeat bone density testing about 4 years later. After adjustment for potentially confounding variables, men with baseline 25(OH)D levels <20 ng/mL had significantly greater 4-year declines in bone density than did men with levels of 20–29 ng/mL or …