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Most guidelines recommend 140/90 mm Hg as the blood pressure target for nondiabetic patients with hypertension. But, no randomized trials of systolic blood pressure (SBP) reduction to ≤130 mm Hg have been conducted in this population.
With funding from three pharmaceutical manufacturers, Italian investigators randomized 1111 nondiabetic hypertensive patients to tight (<130 mm Hg) or usual (<140 mm Hg) SBP control. Patients (age, ≥55) had baseline SBP levels of ≥150 mm Hg after receiving antihypertensive therapy for at least 12 weeks and had at least one other cardiovascular risk factor. Treatment was open-label and individualized and included previous (background) therapy plus various combinations of furosemide, hydrochlorothiazide, ramipril…