CT Screening for Lung Cancer: Early Results

Preliminary outcomes from the DANTE trial show no differences between screening and control groups.

Randomized trials of lung cancer screening by computed tomography are in progress in Europe and the U.S. In one of these, the Italian DANTE Trial, about 2500 heavy smokers (all men; age range, 60–75) have been randomized to annual CT scanning or to no imaging for 5 years. Each participant undergoes an annual general clinical assessment.

In a preliminary report, after a median follow-up of about 3 years, investigators have detected lung cancer in 5% of CT subjects and in 3% of controls. At this point in the study, exactly 20 men have died of lung cancer in each of the two groups.

Comment

Obviously, longer follow-up is planned; it's too early to determine whether lung cancer mortality will be affected by s…

Reviewing Author

Allan S. Brett, MD

Disclosures

Nothing to disclose

Allan S. Brett, MD

Disclosures

Nothing to disclose

CT Screening for Lung Cancer: Early Results

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Reviewing Author