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Because recent reports have raised questions about the benefits and risks of intensive control of glucose in patients with type 2 diabetes (JW Gen Med Jul 30 2009), investigators conducted a systematic review that was focused on cardiovascular disease (CVD; i.e., coronary heart disease, stroke, and peripheral artery disease) outcomes.
In pooled analyses of data from five studies that each involved >500 adults (treatment duration, 3–11 years), intensive glucose control lowered risk for CVD (relative risk, 0.90; 95% confidence interval, 0.83–0.98; 15 fewer events per 1000 patients during 5 years) and coronary heart disease specifically (RR, 0.89; 95% CI, 0.81–0.96; 11 fewer events per 1000 patients during 5 years). No significant differences w…