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The U.S. Preventive Services Task Force (USPSTF) has issued a new guideline about the use of nontraditional markers for coronary heart disease risk to screen patients, particularly those at intermediate risk according to traditional risk factors (Framingham score). The task force evaluated nine nontraditional markers: high-sensitivity C-reactive protein (hs-CRP), ankle-brachial index (ABI), leukocyte count, fasting blood glucose level, periodontal disease, carotid intima–media thickness, coronary artery calcification score as determined by electron-beam computed tomography, homocysteine level, and lipoprotein(a) level.
The USPSTF concluded that evidence is insufficient to assess the balance of benefits and harms of using nontraditional risk …