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In addition to vitamin D's roles in calcium homeostasis and bone metabolism, it might have a function in cancer control. Indeed, in small prospective studies, researchers have noted an inverse association between serum 25-hydroxyvitamim D (25[OH]D) concentration and colorectal cancer. In this nested case-control study that involved 520,000 participants in 10 European countries, investigators assessed the association between pre-diagnostic (i.e., before diagnosis of cancer) serum 25(OH)D concentration and risk for colorectal cancer.
Higher serum 25(OH)D concentration was associated with lower colorectal cancer risk in a dose-response manner. Compared with prediagnostic serum 25(OH)D concentrations of 50 to 75 nmol/L, higher concentrations wer…