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In a 2007 American Cancer Society guideline, magnetic resonance imaging (MRI) screening was recommended as an adjunct to mammography for women whose lifetime breast cancer risk exceeds 20% (JW Gen Med Apr 12 2007). Previous studies have shown MRI to be more sensitive, but less specific, than mammography in such patients. Now, German researchers have compared mammography, MRI, and ultrasound in 687 high-risk women; 10% had BRCA mutations, 27% had personal histories of breast cancer, and 63% had family histories conferring ≥20% lifetime risk. Women received two or three rounds of annual screening with all three modalities.
Screening identified breast cancer in 27 women (16 invasive, 11 ductal carcinoma in situ). Sensitivity and specificity wer…