Blood-Based Gene-Expression Test for Assessing Coronary Artery Disease

Predicting CAD risk was not significantly more accurate with the genetic test than with clinical risk calculation alone.

Researchers have documented the presence of differential gene expression (e.g., genes involved in neutrophil activation, neutrophil apoptosis, NK activation) in peripheral blood samples from patients with coronary artery disease (CAD). In this study, industry-funded U.S. investigators attempted to validate a gene-based peripheral blood test (that includes evaluation of 23 genes) to detect the presence of obstructive CAD (defined as a stenosis ≥50% on quantitative coronary angiography).

Patients without histories of diabetes or CAD who were referred for diagnostic coronary angiography to evaluate potential CAD were enrolled. The predictive model was developed on 640 patients and validated on 526. The gene-expression model was combined with ea…

Reviewing Author

Jamaluddin Moloo, MD, MPH

Disclosures

Grant / Research supportColorado Health Foundation

Jamaluddin Moloo, MD, MPH

Disclosures

Grant / Research supportColorado Health Foundation