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In three randomized controlled studies (total enrollment, 3031 adult patients), outcomes after out-of-hospital cardiac arrest were better with dispatcher-assisted cardiopulmonary resuscitation (CPR) in which only chest compressions were provided than with dispatcher-assisted standard CPR (with rescue breathing), but the difference did not reach significance.
Researchers conducted a meta-analysis of these three trials (the only published randomized studies in which these interventions were compared). Survival to hospital discharge was the primary endpoint in two studies; 30-day survival was the primary endpoint in the third. In the pooled analysis, survival was significantly more likely after compression-only CPR (14% vs. 12%; absolute differ…