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In several studies published in 2010, researchers addressed the safety and efficacy of antiplatelet and anticoagulant agents, as well as interactions between clopidogrel (Plavix) and proton-pump inhibitors (PPIs).
Two observational studies on aspirin and clopidogrel from the same Danish group showed higher risk for bleeding with use of multiple agents or with more-intensive therapy. One study involved 40,000 adults, identified from national registries, who suffered first acute myocardial infarctions (MIs) and received one or more prescriptions for aspirin, clopidogrel, or a vitamin K antagonist. Compared with patients who received aspirin alone, those who received a vitamin K antagonist alone or clopidogrel alone had significantly higher ris…