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In two studies, researchers assessed whether coronary artery calcium (CAC) assessment by computed tomography improved prediction of adverse cardiac events in asymptomatic people with no histories of coronary disease.
In a German study, 4129 people (age range, 45–75) were followed for a median of 5 years; 93 experienced nonfatal myocardial infarctions (MIs) or coronary death. Investigators reclassified intermediate-risk patients (10-year risk by Framingham risk score, 10%–20%) to low risk if their CAC scores were <100 and to high risk if their CAC scores were ≥400; 22% of patients were reclassified based on these cutoffs, and prediction of adverse events improved significantly.
In a Dutch study, 2028 people were followed for a median of 9.2 ye…